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非胰岛素依赖型糖尿病糖尿症(NIDDM)患者其尿自蛋白排泄(UAE)增加与其心血管疾病的发生率增高有一定联系。本文通过检测94例 NI-DDM 患者的 UAE、心血管疾病的发生率及血浆von Willebrand 因子(vWF)浓度(一种内皮机能障碍指示剂),研究血管内皮机能障碍的作用。患者94例,UAE 基础值正常者66例(<15μg/min),随访9—53个月,UAE 基础值仍正常的33例为第1组;基础值上升的33例为第2组。UAE基础值异常者28例(67.1μg/min)为第3组。第1组 vWF 浓度无变化(基础值128%,随访后123%);第2组 vWF 浓度增加(从116增至219%,P<0.0001);第3组 vWF 浓度从157增至207%(P=0.0005)。vWF 基础值改变与微蛋白尿的出现密切相关(R~2=
In patients with non-insulin-dependent diabetes mellitus (NIDDM), increased urinary protein excretion (UAE) is associated with an increased incidence of cardiovascular disease. This study examined the role of endothelial dysfunction in patients with NI-DDM by measuring UAE, the incidence of cardiovascular disease, and the plasma von Willebrand factor (vWF) concentration, an indicator of endothelial dysfunction. There were 94 patients with normal basal value of UAE, 66 patients (<15μg / min) with normal baseline UAE value, followed up for 9-53 months. 33 cases with normal UAE basal value were group 1 and 33 cases with basal value were group 2. 28 cases (67.1 μg / min) with abnormal UAE basal values were in group 3. The vWF concentration in group 1 was unchanged (basal value 128%, follow-up 123%); vWF concentration was increased in group 2 (from 116 to 219%, P <0.0001); vWF concentration in group 3 was increased from 157 to 207% P = 0.0005). VWF changes in basic values and the occurrence of microalbuminuria are closely related (R ~ 2 =