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目的 :应用精子卵细胞内注射 (ICSI)解决因严重少、弱精子症和受精障碍不育夫妇的受孕问题。方法 :应用 ICSI和体外受精 /胚胎移植 (IVF-ET)技术。结果 :对 1 5对严重少、弱精子症和受精障碍不育夫妇进行了共 1 6个周期的 ICSI。共取卵 1 3 6个 (生殖泡期 1 4个 ,M11 7个 ,M2 1 0 5个。) ,平均取卵 8.5个 /周期 ,成熟卵率 77.2。ICSI 1 0 3个卵 ,受精 67个 ,受精率 65 .0。产生胚胎 5 9个 ,卵裂率 88.1。每周期获得胚胎 3 .7个。临床妊娠 6例 (双胎 2例 )。胚胎种植率为 1 3 .6。但是 ,2例妊娠于早期发生流产。现已经诞生 2例正常新生儿 ,另 2例于正常妊娠中。结论 :在常规 IVF-ET中出现受精异常和严重精液异常 ,经一般治疗无效的不育夫妇 ,ICSI应作为治疗的首选方法。
OBJECTIVE: To apply sperm oocyte intracytoplasmic injection (ICSI) to solve the problem of conception in infertile couples with severe oligospermia, asthenospermia and fertilization disorders. Methods: ICSI and in vitro fertilization / embryo transfer (IVF-ET) techniques were used. RESULTS: A total of 16 cycles of ICSI were performed on 15 infertile couples with severe oligozoospermia and asthenospermia. A total of 136 eggs (14 reproductive period, 7 M11 and M2105) were obtained, with an average of 8.5 eggs / cycle. The mature egg rate was 77.2%. ICSI 1 0 3 eggs, fertilization 67, fertilization rate 65 .0 . 59 embryos were produced with a cleavage rate of 88.1%. Embryos get 3.7 per cycle. 6 cases of clinical pregnancy (twins in 2 cases). Embryo implantation rate was 13.6. However, 2 cases of pregnancy occurred in the early abortion. Has now been born two cases of normal newborns, the other two cases in normal pregnancy. CONCLUSIONS: ICSI should be the preferred method of treatment for infertile couples with abnormal fertilization and severe semen abnormalities in conventional IVF-ET.