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目的:观察左卡尼汀短期治疗男性少弱精子症后精液质量的变化及行卵细胞胞质内单精子注射(intracytoplasmic sperm injection,ICSI)助孕治疗后的临床结果。方法:研究对象为根据WHO标准检测精液分析结果为少弱精子症者129例,治疗组42例服用左卡尼汀2周后应用ICSI,对照组87例单纯应用ICSI助孕技术。对比治疗组患者用药前后精液精子浓度、活动率、(a+b)级精子百分率、畸形率指标,治疗组与对照组对比ICSI后受精率、卵裂率、有效胚胎率、临床妊娠率。结果:治疗组患者治疗后(a+b)级精子百分率(13.5±10.7)%,较治疗前(9.6±7.2)%提高(P<0.05),治疗组ICSI操作后有效胚胎率77.50%,明显高于对照组69.04%(P<0.05)。结论:左卡尼汀短期治疗能够改善精子质量,并有助于少弱精子症患者提高ICSI治疗的成功率。
OBJECTIVE: To observe the changes of semen quality after levocarnitine short-term treatment of oligozoospermia and the clinical results after intracytoplasmic sperm injection (ICSI). Methods: The study included 129 patients with oligoasthenospermia who underwent semen analysis according to WHO criteria. 42 patients in the treatment group were given ICSI 2 weeks after taking levocarnitine, and 87 patients in the control group were treated with ICSI alone. The sperm concentration, activity rate, (a + b) sperm percentage and malformation rate of the patients in the treatment group before and after treatment were compared. The fertilization rate, cleavage rate, effective embryo rate and clinical pregnancy rate were compared between the treatment group and the control group after ICSI. Results: The percentage of sperm in the treatment group after treatment was (13.5 ± 10.7)% (9.6 ± 7.2)% (P <0.05), and the effective embryo rate in the treatment group was 77.50% after ICSI operation Higher than the control group 69.04% (P <0.05). Conclusion: Short-term levocarnitine treatment improves sperm quality and contributes to the success of ICSI-treated patients with oligoasthenospermia.