当前艾滋病的治疗为高效抗逆转录病毒疗法,使用的药物主要为逆转录酶抑制剂和蛋白酶抑制剂,但效果并不十分令人满意。HIV进入抑制剂通过阻止HIV进入靶细胞抑制病毒感染,是抗HIV新药研究中最活跃的领域之一。由于天然产物具有来源广泛、结构多样、有效和低毒等特点,使天然来源HIV进入抑制剂成为近年来研究和开发新型抗HIV药物的热点。对近年来天然来源HIV进入抑制剂的研究进行综述。 Currently, AIDS treatment is highly effective antiretroviral therapy. The drugs used are mainly reverse transcriptase inhibitors and protease inhibitors, but the results are not very satisfactory. HIV entry inhibitors are one of the most active areas in the study of new anti-HIV drugs by preventing HIV from entering the target cells and inhibiting viral infection. Due to its wide variety of sources, diverse structures, effective and low toxicity, naturally occurring HIV inhibitors have become hot spots for research and development of new anti-HIV drugs in recent years. In recent years, natural sources of HIV entry inhibitors are reviewed.