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苏云金芽孢杆菌(Bacillus thuringiensis)能产生杀虫晶体蛋白等多种活性成分,是目前应用最广泛的微生物杀虫剂。本文采用生物信息学方法,系统分析了由本实验室完成全基因组测序的苏云金芽孢杆菌YBT-1520、CT-43和BMB171 3个菌株的双组分信号转导系统(Two-componentsignal transduction system,TCS)的分布、结构及功能,并初步构建了部分TCS的调控网络关系图。本研究旨在为深入研究苏云金芽孢杆菌的生长、代谢以及毒力因子的表达与调控,全面了解伴孢晶体的形成机制开辟新的研究方向。
Bacillus thuringiensis can produce insecticidal crystal protein and other active ingredients, is currently the most widely used microbial pesticides. This paper systematically analyzed the two-components signal transduction system (TCS) of three strains of Bacillus thuringiensis YBT-1520, CT-43 and BMB171, which were sequenced by our laboratory, using bioinformatics methods. The distribution, the structure and the function, and preliminarily constructed the part of TCS regulation network relation diagram. The purpose of this study is to further study the growth and metabolism of Bacillus thuringiensis and the expression and regulation of virulence factors, and to fully understand the formation mechanism of the sporozoite crystal and open up new research directions.