论文部分内容阅读
目的了解白细胞介素-6（IL-6）,肿瘤坏死因子（TNF）在食管癌组织中表达和预后的关系。方法用IL-6和TNF-α的单克隆抗体对60例食管瘤组织进行免疫组织化学PAP法染色。结果随食管癌细胞分化程度的降低,IL-6和TNF-α的表达呈增强趋势。在同一细胞分化等级中,IL-6和TNF-α表达弱者的预后差于表达强者。结论食管瘤组织中IL-6和TNF-α水平的高低与食瘤预后有密切关系。
Objective To investigate the relationship between the expression and prognosis of interleukin-6 (IL-6) and tumor necrosis factor (TNF) in esophageal cancer. Methods Immunohistochemical PAP staining was performed on 60 esophageal neoplasms with monoclonal antibodies against IL-6 and TNF-α. Results With the decrease of differentiation of esophageal cancer cells, the expression of IL-6 and TNF-α increased. In the same grade of cell differentiation, the poor prognosis of IL-6 and TNF-α expression is worse than that of strong expression. Conclusion The levels of IL-6 and TNF-α in esophageal neoplasms are closely related to the prognosis of esophageal cancer.