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应用免疫组化及计算机图像分析技术检测了５６例ＩｇＡ肾病患者肾间质ＣＤ４＋ＣＤ８＋细胞（简称为ＣＤ４＋、ＣＤ８＋）及间质纤维化的变化。结果显示：ＩｇＡ肾病患者肾间质内ＣＤ４＋、ｃＤ８·增多，间质纤维化面积显著增大，ＣＤ４＋／ＣＤ８”的比值与正常对照组无差异；尿红细胞＞２００Ｘｌ０６／Ｌ组ＣＤ４＋计数增加更为显著；伴高血压的患者ＣＤ４＋、ＣＤ８＋计数增加也更显著；ＣＤ４＋、ＣＤ８＋计数与血肌酐和肾间质病理改变分级均显著正相关，而ＣＤ４＋／ＣＯ８＋随肾间质病理改变的加重而降低。结果提示细胞免疫可能通过损伤肾小管－间质参与了ＩｇＡ肾病的发病机制，并影响患者的预后。
Immunohistochemistry and computer image analysis were used to detect the changes of renal interstitial CD4 + CD8 + cells (CD4 +, CD8 +) and interstitial fibrosis in 56 patients with IgA nephropathy. The results showed that: CD4 +, cD8 · increased, the area of interstitial fibrosis in IgA nephropathy patients increased significantly, the ratio of CD4 + / CD8 "was no difference with normal control group; urinary red blood cells> 200Xl06 / L group CD4 + count more Significantly, CD4 + and CD8 + counts were also significantly increased in patients with hypertension. The counts of CD4 + and CD8 + were significantly and positively correlated with the grading of serum creatinine and renal interstitium, while CD4 + / CO8 + was decreased with the increase of pathological changes of renal interstitium. The results suggest that cellular immunity may be involved in the pathogenesis of IgA nephropathy by affecting the tubulointerstitial and affecting the prognosis of patients.