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猪繁殖与呼吸综合征(porcine reproductive and respiratory syndrome,PRRS)是由猪繁殖与呼吸综合征病毒(Porcine reproductive and respiratory syndrome virus,PRRSV)引起的一种以导致怀孕母猪流产和仔猪呼吸困难为主要特征的疾病,PRRS已给养猪业造成巨大的经济损失。微RNA(miRNA)是一类重要的转录后调控基因表达的微小RNA分子,广泛存在于各种生物体内。文章综述了miRNA-23、miRNA-26、miRNA-29、miRNA-125、miRNA-181、miRNA-506对PRRSV在猪肺泡巨噬细胞(porcine alveolar macrophages,PAM)或非洲绿猴肾上皮细胞(african green monkey kidney epithelial cell line,Marc-145)中复制的调控作用。
Porcine reproductive and respiratory syndrome (PRRS) is caused by porcine reproductive and respiratory syndrome virus (PRRSV), which is mainly caused by miscarriage and piglet dyspnoea in pregnant sows Characterized by the disease, PRRS has caused huge economic losses to the pig industry. MicroRNAs (miRNAs) are a class of important microRNA molecules that regulate post-transcriptional gene expression and are found in a wide range of organisms. This review summarizes the effects of miRNA-23, miRNA-26, miRNA-29, miRNA-125, miRNA-181 and miRNA-506 on the expression of PRRSV in porcine alveolar macrophages (PAM) or African green monkey kidney epithelial cells green monkey kidney epithelial cell line, Marc-145).