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目的 :研究自发性高血压大鼠 (SHR)动脉压力感受性反射 (ABR)功能的改变及其与心、肾、血管等靶器官损伤(TOD)间的关系。 方法 :分别测定清醒、自由活动状态下 SHR及 WKY大鼠 2 4 h动脉血压、心率、血压波动性 (BPV)及心率波动性 (HRV) ;测定 ABR对心率及对血压的控制功能 (ABR- HP,ABR- BP) ;按预先制定的评分标准对高血压 TOD进行评估。 结果 :SHR的 2 4 h收缩压 (SBP)、舒张压 (DBP)及收缩压波动性 (SBPV)、舒张压波动性 (DBPV)显著高于对照 WKY大鼠 ,心率二者间无差异 ,但 SHR的 HRV显著低于 WKY大鼠。 SHR的 ABR功能显著低于 WKY大鼠 (P<0 .0 1)。 SHR靶器官损伤明显 ,TOD评分显著高于对照的 WKY大鼠。直线相关分析结果表明 :SHR的 TOD得分与 SBP及 DBP呈正相关 (P<0 .0 5 ) ;与 BPV也呈正相关 (P<0 .0 1) ;与 ABR功能呈负相关 (P<0 .0 1) ;TOD得分与心率间无相关关系 ,但与心率波动性间呈负相关 (P<0 .0 5 )。 TOD得分与 ABR功能间相关系数高于与血压、BPV等其他血流动力学变量间相关系数。多元逐步回归分析结果进一步表明 :在血压、心率、BPV、HRV及 ABR功能等一系列变量中 ,ABR功能对 SHR的靶器官损伤影响作用最强 ,血压水平次之。 结论 :ABR功能与高血压 TOD密切相关 ,ABR功能降低可能加重高血
Objective: To investigate the changes of arterial baroreflex (ABR) function in spontaneously hypertensive rats (SHR) and its relationship with the target organ damage (TOD) such as heart, kidney and blood vessels. Methods: Arterial blood pressure, heart rate, blood pressure variability (BPV) and heart rate variability (HRV) were measured in SHR and WKY rats at awake and free state respectively. The ABR- HP, ABR-BP); Hypertensive TOD was assessed according to pre-established scoring criteria. Results: SBP, DBP, SBPV and DBPV at 24 h in SHR group were significantly higher than those in control WKY group, but there was no difference in heart rate between two groups The HRV of SHR was significantly lower than that of WKY rats. The ABR function of SHR was significantly lower than that of WKY rats (P <0.01). The target organs of SHR were obviously damaged and the TOD score was significantly higher than that of the control WKY rats. The linear correlation analysis showed that the TOD score of SHR was positively correlated with SBP and DBP (P <0.05), positively correlated with BPV (P <0.01) and negatively with ABR (P <0.05). There was no correlation between TOD score and heart rate, but negatively correlated with heart rate volatility (P <0.05). The correlation coefficient between TOD score and ABR function was higher than that between blood pressure, BPV and other hemodynamic parameters. Multiple stepwise regression analysis further showed that ABR function had the strongest effect on the target organ damage of SHR and the blood pressure level was the second in a series of variables such as blood pressure, heart rate, BPV, HRV and ABR function. Conclusion: The function of ABR is closely related to the TOD of hypertension, and the decrease of ABR may aggravate the high blood