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摘要目的开发一种将对比剂播散整合到数字体模中的方法,用以估算CT扫描中器官的辐射剂量。材料与方法将一个特定病人的心血管系统生理药代动力学(PBPK)模型分别整合到58个大范围心脏-躯干(XCAT)病人模型中。PBPK模型包括血管房室模型,并且每个XCAT模型的器官各不相同。对于标准的注射方案,体内对比剂药代动力学是根据一系列病人特异性的碘量-平衡微分方程式描述的,这一方程的解为每个房室提供对比剂的浓度时间曲线。各器官
Abstract Objective To develop a method for integrating contrast media into digital phantoms to estimate the radiation dose of an organ in a CT scan. MATERIALS AND METHODS One patient-specific cardiovascular pharmacokinetic (PBPK) model was integrated into 58 large-scale cardiac-trunk (XCAT) patient models, respectively. The PBPK model includes a vascular compartment model, and each XCAT model organ varies. For standard injection protocols, in vivo contrast agent pharmacokinetics are described in terms of a series of patient-specific Iodine-Balanced Differential Equations, the solution of this equation providing a concentration versus time profile for each compartment. Various organs