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目的：研究Ｆａｓ抗原在胃癌组织中的表达和意义，探讨Ｆａｓ抗原表达与胃癌细胞凋亡的关系。方法：应用免疫组织化学方法及脱氧核糖核酸末端转移酶介导的缺口末端标记（ＴＵＮＥＬ）技术，对５９例胃癌组织中的Ｆａｓ抗原表达、凋亡细胞进行原位观察和比较。结果：Ｆａｓ抗原表达阳性率为４５．７６％。Ｆａｓ抗原在胃癌中的表达与患者的性别、年龄、组织学类型、肿瘤大小及浸润深度无明显关系（Ｐ＞０．０５），与淋巴结转移和临床分期有关（Ｐ＜０．０５）。Ｆａｓ抗原表达阳性胃癌组织细胞凋亡指数明显高于Ｆａｓ抗原阴性组（Ｐ＜０．０１）。结论：Ｆａｓ抗原表达异常在胃癌淋巴结转移中可能起重要作用，检测Ｆａｓ抗原表达对预测胃癌预后有一定的参考价值。Ｆａｓ抗原对胃癌组织细胞凋亡具有促进性调控作用。
Objective: To study the expression and significance of Fas antigen in gastric cancer and to explore the relationship between Fas antigen expression and gastric cancer cell apoptosis. METHODS: Fas antigen expression and apoptotic cells were observed and compared in situ in 59 gastric cancer tissues by immunohistochemistry and nick end labeling (TUNEL) mediated by DNA terminal transferase. Results: The positive rate of Fas antigen expression was 45.76%. The expression of Fas antigen in gastric cancer was not significantly related to the patient’s gender, age, histological type, tumor size, and depth of invasion (P>0.05). It was related to lymph node metastasis and clinical stage (P<0.05). The apoptosis index of Fas antigen positive gastric cancer tissue was significantly higher than that of Fas antigen negative group (P<0.01). Conclusion: Abnormal expression of Fas antigen may play an important role in the lymph node metastasis of gastric cancer. The detection of Fas antigen expression has a certain reference value in predicting the prognosis of gastric cancer. Fas antigen can promote the regulation of gastric cancer cell apoptosis.