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研究不同剂量 ６０Ｃｏγ射线诱发人外周血淋巴细胞染色体畸变率的观察值和预期值间的关系及其易位的类型和易位在细胞中的分布，为用易位率进行早先照射和慢性小剂量长期照射进行回顾性剂量估算提供必要的理论依据。用４号和７号全染色体探针，采用荧光原位杂交技术和连续 Ｇｉｅｍｓａ染色法分析不同剂量点 ６０Ｃｏ γ射线离体照射诱发人外周血淋巴细胞染色体畸变。对比观察发生于４号和７号染色体的畸变数和根据其物理相对长度计算的预期值，发现４号和 ７号染色体的畸变观察值和预期值非常吻合；除０．２５Ｇｙ剂量点易位在细胞中的分布不符合泊格分布，为过离散分布外，其余各剂量点易位在细胞中的分布服从或接近泊松分布；各剂量点观察到的易位中，经 ５２ｈ培养后，不完全易位较完全易位为多。其中，又以荧光部分不带着丝粒的易位（Ｔ（Ａｂ））占多数。 ４号和 ７号的畸变观察值和预期值非常吻合，说明它们发生畸变的频率与其物理长度或ＤＮＡ含量成正比。
The relationship between the observed value and the expected value of chromosomal aberration in human peripheral blood lymphocytes induced by different doses of 60Coγ-ray and the type of translocation and the distribution of translocation in the cells were investigated. Long-term exposure for retrospective dose estimates provide the necessary theoretical basis. Chromosome aberration of human peripheral blood lymphocytes induced by 60Co γ-ray irradiation in different dose points was analyzed by fluorescence in situ hybridization and continuous Giemsa staining with chromosome 4 and 7 whole chromosome probes. A comparison of the number of aberrations that occurred on chromosomes 4 and 7 and the expected value based on their relative physical lengths found that the observed aberrations on chromosomes 4 and 7 were in good agreement with the expected values; The distribution in the cells did not accord with the Bogee distribution. For the overdispersed distributions, the distributions of the other translocation sites in the cells obeyed or approached the Poisson distribution. In the observed translocation at each dose point, More complete translocation than complete translocation. Of these, the majority of translocations (T (Ab)) in which the fluorescent moiety is free of centromere. Distortion observations Nos. 4 and 7 are in good agreement with the expected values, indicating that the frequency of their distortion is proportional to their physical length or DNA content.