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目的探讨G蛋白偶联受体30(GPR30)及血管内皮生长因子(VEGF)蛋白在子宫内膜样腺癌组织中的阳性表达率及其与临床病理特征的关系,分析GPR30及VEGF蛋白在子宫内膜腺癌发生、发展中的作用。方法采用免疫组化SP法检测GPR30与VEGF蛋白在93例子宫内膜腺癌、37例不典型增生子宫内膜和31例正常子宫内膜组织中的阳性表达率。结果GPR30和VEGF蛋白在子宫内膜腺癌中的阳性表达率分别为65.59%和58.06%,均显著高于不典型增生子宫内膜及正常子宫内膜(P<0.05)。随临床分期升高及淋巴结转移,GPR30及VEGF蛋白在子宫内膜腺癌中的阳性表达率均明显升高,差异有统计学意义(P<0.05),但不同肌层浸润深度比较差异无统计学意义(P>0.05);随着组织学分级升高,GPR30蛋白阳性表达率明显升高,VEGF蛋白阳性表达率则无显著变化。GPR30与VEGF蛋白在子宫内膜腺癌组织中的阳性表达率呈正相关。结论GPR30及VEGF蛋白的阳性表达率与子宫内膜腺癌的发生、发展有关,GPR30及VEGF检测有助于评估子宫内膜腺癌的生物学行为和预后。
Objective To investigate the positive expression rate of GPR30 and VEGF in endometrial adenocarcinoma and its relationship with clinicopathological features. To investigate the relationship between the expression of GPR30 and VEGF protein in uterus Endometrial adenocarcinoma occurs, the role of development. Methods The positive rate of GPR30 and VEGF protein in 93 cases of endometrial adenocarcinoma, 37 cases of atypical hyperplasia endometrium and 31 cases of normal endometrium was detected by immunohistochemical SP method. Results The positive rates of GPR30 and VEGF protein in endometrial adenocarcinoma were 65.59% and 58.06%, respectively, which were significantly higher than those in atypical hyperplasia endometrium and normal endometrium (P <0.05). With the clinical stage and lymph node metastasis, the positive rates of GPR30 and VEGF protein in endometrial adenocarcinoma were significantly increased (P <0.05), but there was no statistical difference in the depth of invasion (P> 0.05). With the increase of histological grade, the positive expression rate of GPR30 protein and the positive expression rate of VEGF protein did not change significantly. GPR30 and VEGF protein in endometrial adenocarcinoma positive expression rate was positively correlated. Conclusion The positive rate of GPR30 and VEGF protein is related to the occurrence and development of endometrial adenocarcinoma. The detection of GPR30 and VEGF may be helpful to evaluate the biological behavior and prognosis of endometrial adenocarcinoma.