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利用细胞凋亡抑制基因ｂｃｌ－２单克隆抗体及免疫组化ＬＳＡＢ法，对正常外阴皮肤、慢性外阴营养不良、不典型增生和外阴癌组织进行标记，发现ｂｃｌ－２蛋白在正常外阴皮肤基底层中有弱阳性表达；在增生型营养不良、不典型增生及外阴癌组织中表达率有不同程度增高，与外阴硬化苔癣型和混合型营养不良有显著差异（Ｐ＜０．０５，Ｐ＜０．０５，Ｐ＜０．０１）；而增生型与不典型增生ｂｃｌ－２基因蛋白表达无明显差异（Ｐ＞０．０５）；外阴癌的表达率最高；该基因蛋白表达与外阴癌细胞分化程度有关，与临床分期无关。
Using bcl-2 monoclonal antibody and immunohistochemical LSAB method to detect normal vulvar skin, chronic vulvar dystrophy, dysplasia and vulvar cancer tissues, it was found that bcl-2 protein in normal vulvar skin basement layer In vulvar dysplasia, dysplasia and vulvar cancer tissues, the expression rates were increased in varying degrees, with vulvar lichen sclerosus and mixed malnutrition have significant differences (P <0.05, P < 0.05, P <0.01). The expression of bcl-2 protein in proliferative and atypical hyperplasia had no significant difference (P> 0.05), while the expression of vulvar cancer was the highest The degree of differentiation, has nothing to do with clinical stage.