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目的:检测2型糖尿病(DM2)血浆tPA、PAI-1、uPA及uPAR水平,探讨其临床价值。方法:分别以ELISA检测尿蛋白正常组、尿蛋白阳性组、严重尿蛋白组和对照组的tPA、PAI-1、uPA及uPAR水平。结果:与对照组相比,尿蛋白正常组的tPA和PAI-1变化不明显(P>0.05);尿蛋白阳性组tPA活性明显下降(P<0.05),PAI-1活性明显升高(P<0.05);严重蛋白尿组tPA活性明显下降(P<0.05),PAI-1活性明显升高(P<0.05);uPA及uPAR在各组间差异无显著性意义(均P>0.05)。结论:DM2患者蛋白尿的程度与tPA、PAI-1的水平密切相关,检测tPA、PAI-1的变化可反映其肾病状态。
Objective: To investigate the plasma levels of tPA, PAI-1, uPA and uPAR in type 2 diabetes mellitus (DM2) and to investigate their clinical value. Methods: The levels of tPA, PAI-1, uPA and uPAR in normal urinary protein group, urinary protein positive group, severe urinary protein group and control group were detected by ELISA respectively. Results: The levels of tPA and PAI-1 in urinary protein in normal group were not significantly different from those in control group (P> 0.05), and the activity of tPA in urine protein positive group was significantly decreased (P <0.05) and the activity of PAI-1 <0.05). In severe proteinuria, tPA activity was significantly decreased (P <0.05) and PAI-1 activity was significantly increased (P <0.05). There was no significant difference between uPA and uPAR in each group (all P> 0.05). Conclusion: The level of proteinuria in patients with DM2 is closely related to the levels of tPA and PAI-1. The changes of tPA and PAI-1 may reflect the status of nephropathy.