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Sustained complex cross-talk between the immune system and the nervous system plays a vital role in retaining homeostasis in a healthy individual.One of the central regulatory mechanisms involved is the existence and functions of β2-adrenergic receptors(β2AR) on T lymphocytes.This article reviews research progress made recently,including the expression of adrenergic receptors on T lymphocytes,the structure and intracellular pathways of β2AR,the activation of β2AR by either endogenous or exogenous agonists,and the effect of β2AR stimulation on T cells which alters T cell proliferation,differentiation,cytokine production and T-helper-mediated antibody production.Furthermore,we discuss the roles of β2AR played in the pathogenesis and treatment of autoimmune diseases.
Sustained complex cross-talk between the immune system and the nervous system plays a vital role in retaining homeostasis in a healthy individual. One of the central regulatory mechanisms involved is the existence and functions of β2-adrenergic receptors (β2AR) on T lymphocytes. article reviews research progress made recently, including the expression of adrenergic receptors on T lymphocytes, the structure and intracellular pathways of β2AR, the activation of β2AR by either endogenous or exogenous agonists, and the effect of β2AR stimulation on T cells which alters T cell proliferation , differentiation, cytokine production and T-helper-mediated antibody production. Thermore, we discuss the roles of β2AR played in the pathogenesis and treatment of autoimmune diseases.