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作者报告利福平重复给药引起急性肾衰竭2例t: 一59岁妇女每星期3天服用对氨水杨酸、异菸肼和利福平以治疗腹部结核,9个月后出现恶心,偶然有腹泻,当即停药。一个月后重新给药,服用利福平2小时后,病人中腹部疼痛、呕吐、寒战、不适、5天后无尿。入院时血浆尿素242毫克/100毫升,肝活检正常,肾活检显示急性肾小管坏死,细胞坏死区可检出C_3′,未发现结合免疫球蛋白或纤维素,亦未检得
The authors report two cases of acute renal failure caused by repeated administration of rifampicin. T: A 59-year-old woman takes naltrexone, isoniazid and rifampin to treat abdominal tuberculosis three days a week. After nine months, he developed nausea and chance Have diarrhea, stop taking medicine immediately. Remedy one month later, 2 hours after taking rifampicin, the patient had abdominal pain, vomiting, chills, discomfort, and no urine after 5 days. Blood urea 242 mg / 100 ml on admission, normal liver biopsy, acute tubular necrosis on renal biopsy, C_3 ’in necrotic area, no immunoglobulin or cellulose binding, nor test