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目的 :观察环丙沙星治疗复治涂阳肺结核的疗效。方法 :将 146例复治涂阳肺结核病人分为治疗组 77例 (男性 51例 ,女性 2 6例 ,年龄 4 6±s 11a) ,对照组 69例 (男性 4 5例 ,女性 2 4例 ,年龄 4 9±11a) ,2组均应用HRZE方案 :异烟肼 (H) 0 .3g/d ;利福平 (R) 0 .4 5g/d(体重 >60kg者 0 .6g/d) ;吡嗪酰胺 (Z) 1.5g/d ;乙胺丁醇 (E) 0 .75g/d ,吡嗪酰胺为bid ,其余 3药均晨间空腹顿服 ,治疗组加环丙沙星 ,体重≥ 55kg者 0 .3g ,体重 <55kg者 0 .2 g ,po ,bid ,连用 6mo。结果 :治疗组和对照组治疗mo 6痰菌阴转率分别为 93%和 64% (P <0 .0 1) ,有显著性差异。结论 :环丙沙星可推荐治疗复治涂阳肺结核
Objective: To observe the curative effect of ciprofloxacin on retreatment of smear positive pulmonary tuberculosis. Methods: One hundred and sixty-six patients with retreatment of smear positive pulmonary tuberculosis were divided into treatment group (n = 51), female (26 males, age 46 ± s11a) and control group (n = Age 4 9 ± 11a), HRZE regimen was used in both groups: isoniazid (H) 0.3g / d, rifampin 0.45g / d (body weight> 60kg, 0.6g / d) Pyrazinamide (Z) 1.5g / d; ethambutol (E) 0.75g / d, pyrazinamide bid, the rest of the three drugs are morning fasting Dayton clothing, the treatment group plus ciprofloxacin, body weight ≥ 55kg who 0 .3g, weight <55kg were 0.2 g, po, bid, once every 6mo. Results: The sputum negative conversion rate in the treatment group and the control group was 93% and 64% (P <0.01), respectively, with significant difference. Conclusion: Ciprofloxacin can be recommended for the treatment of smear positive pulmonary tuberculosis