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以500mg/kg,100mg/kg,50mg/kg,10mg/kg,0mg/kg醋酸铅在第6天～12天给孕小白鼠灌胃(容积1％),结果见500mg/kg,100mg/kg,10mg/kg剂量组胚胎吸收率增高,500mg/kg组达100％。100mg/kg,50mg/kg剂量,可导致胎鼠体重降低,胸骨骨化完整率降低,在100mg/kg组胎鼠近端趾骨、尾椎的骨化程度低于对照组。另外,实验见有胎鼠肝大现象。本次实验未见胎鼠畸形。作者认为,醋酸铅经口给予小白鼠可产生较大的胚胎毒性,影响胎鼠的体重、内脏、骨骼发育,提出了致畸作用与铅的进入途径及给予量有关等一系列问题。
500mg/kg, 100mg/kg, 50mg/kg, 10mg/kg, 0mg/kg lead acetate was given to the pregnant mice on the 6th to the 12th day (gastric volume 1%). The results were 500mg/kg, 100mg/kg. Absorption rate of embryos at the 10 mg/kg dose group increased, and reached 100% in the 500 mg/kg group. The doses of 100mg/kg and 50mg/kg could cause the fetal mice to lose weight and reduce the integrity of the sternal ossification. The degree of ossification of the proximal phalanx and caudal vertebrae in the 100mg/kg group was lower than that in the control group. In addition, the experiment shows that fetal rat liver phenomenon. No fetal mouse malformation was seen in this experiment. The author believes that oral administration of lead acetate to rats may have a greater embryonic toxicity, affect the fetal rat body weight, internal organs, bone development, put forward a series of problems of teratogenic effects and lead into the way and the amount given.