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目的观察国产格列齐特的致畸作用。②方法对受孕后第６天Ｗｉｓｔａｒ大鼠分别以８５，１７０，６８０ｍｇ／ｋｇ体质量的国产格列齐特（容积为５ｍＬ／ｋｇ体质量）灌胃给药，每天１次，连用１０ｄ；同步设立生理盐水组和敌枯双（５ｍｇ／ｋｇ体质量）对照组。于妊娠第２０天剖腹，取出胎鼠，观察并记录各组活胎数、死胎数以及活胎鼠生长发育等情况。③结果格列齐特各剂量组胚胎数损失率、活胎生长、发育等指标与生理盐水组相比，差异均无显著性（χ２＝０．３７５～３．０９８，Ｐ＞０．０５；Ｆ＝０．０３２～０．１７８，Ｐ＞０．０５）。④结论国产格列齐特无致畸作用
Objective To observe the teratogenic effects of domestic gliclazide. Methods On the 6th day after conception, Wistar rats were intragastrically administrated with domestic gliclazide of 85,170,680mg / kg body weight (volume of 5mL / kg body weight), once a day for 10 days. The normal saline group and the control group (5mg / kg body weight) control group were established. Caesarean section was performed on the 20th day of gestation and the fetus was taken out. The number of live fetuses, the number of stillbirths and the growth and development of live fetus were observed and recorded. ③ Results There was no significant difference in the number of embryo loss, live fetus growth and development among all the doses of gliclazide (χ2 = 0.375 ~ 3.098, P> 0.05; F = 0.032 ~ 0.178, P> 0.05). ④ Conclusion Domestic gliclazide has no teratogenic effect