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类固醇激素的免疫抑制作用早已为人们熟知,并已有资料提示它与妊娠期间母体细胞免疫机能降低有关。但由于在这些研究中所用的激素浓度大大高于孕妇血循环中的激素浓度,而接近胎盘母-胎交界处的激素浓度,故过去曾认为类固醇激素发挥免疫抑制作用的部位只在母-胎交界处。本文作者利用细胞毒试验研究了不同浓度的雌三醇和黄体酮在体外对淋巴细胞反应性的影响,以探讨在妊娠期间循环浓度的激素对母体免疫机能的影响。
The immunosuppressive effects of steroid hormones have long been well known and data suggest that it is associated with reduced maternal cellular immunity during pregnancy. However, since the concentrations of hormones used in these studies are much higher than those in the bloodstream of pregnant women and close to the hormonal concentrations at the maternal-fetal junction of the placenta, steroid hormones were previously thought to exert immunosuppressive effects only at the maternal-fetal interface Department. The authors used cytotoxicity assays to study the effects of different concentrations of estriol and progesterone on lymphocyte reactivity in vitro to investigate the effects of circulating concentrations of hormones on maternal immune function during pregnancy.