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研究了手性辅基诱导Pt/Al_2O_3催化的β-脱氢氨基酸酯的非均相不对称氢化,成功地氢化了一系列β-脱氢氨基酸酯的底物,得到了很好的转化率和dr值(dr值可高达5.2∶94.8).提供了一种非常高效、便捷的关于β-脱氢氨基酸酯的不对称氢化方法,产物可以作为西他列汀药物重要中间体.
The heterogeneous asymmetric hydrogenation of Pt / Al 2 O 3 -catalyzed β-dehydroamino esters induced by chiral prosthetic groups was studied. A series of β-dehydroamino acid ester substrates were hydrogenated successfully and good conversion rates were obtained dr value of up to 5.2: 94.8) provides a very efficient and convenient method for asymmetric hydrogenation of β-dehydroabietic acid esters, which can be used as an important intermediate for sitagliptin drugs.