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通过对移居高海拔地区（3800米），不同时间的实验家兔骨髓组织体视学研究发现：低氧影响红、黄骨髓比例的变化不显著，但组织内血窦体积和数量均有明显增加；幼红细胞造血岛数量，在进入高原1周后有较多增长，随后又有所下降，但仍维持较高水平；骨髓组织中各类细胞，在高原环境下均发生程度不等的胞质水肿，核质比下降，其中以巨噬细胞、网状细胞、原红细胞改变较明显；细胞质内各种细胞器改变的总趋势为，结构肿胀，并且松散，数量减少；幼红细胞血岛中心巨噬细胞内次级溶酶体（噬红细胞小体）的数量、体积均有明显增大。
By studying the bone marrow tissue of rabbits at different time of high altitude (3800 m), we found that there was no significant change in the ratio of red and yellow bone marrow affected by hypoxia, but the volume and number of sinusoids in the tissue were significantly increased ; The number of hematopoietic cells of erythrocytes increased after 1 week of entering the plateau, then decreased again, but still maintained a high level; all kinds of cells in bone marrow tissue had varying degrees of cytoplasm in the plateau Edema, nuclear to cytoplasm ratio decreased, macrophages, reticulocytes and erythroblasts changed more obviously. The general trend of various organelles in the cytoplasm was that the structure was swollen, and loose and the number decreased. Macrophage erythrocytes center Intracellular secondary lysosomes (red blood cells) the number of bodies, the volume was significantly increased.