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目的 :比较头孢呋辛、头孢布烯序贯疗法与单用头孢呋辛静脉输注及头孢哌酮静脉输注治疗小儿肺炎的药物经济学效果。方法 :根据文献选择两个研究 ,分别分为序贯疗法组和对照组接受治疗 ,运用药物经济学的成本 -效果分析方法进行评价。结果 :两个研究中 ,无论是痊愈率还是有效率 ,序贯疗法组的成本效果比均低于各自的对照组。结论 :治疗小儿肺炎 ,头孢布烯序贯疗法与单纯静脉输注相比 ,可降低医疗费用 ,减少病人的负担 ,具有药物经济学意义。
OBJECTIVE: To compare the pharmacological effects of cefuroxime and ceftibuten sequential therapy with intravenous cefuroxime and cefoperazone intravenous infusion in children with pneumonia. METHODS: Two studies were selected according to the literature, and were divided into sequential therapy group and control group, respectively, and were evaluated by the cost-effectiveness analysis method of pharmacoeconomics. Results: In both studies, the cost-effectiveness ratio of the sequential therapy group was lower than that of the respective control group, both in terms of cure rate and effectiveness. Conclusion: The treatment of pediatric pneumonia, ceftibuten sequential therapy compared with simple intravenous infusion, can reduce medical costs and reduce the burden on patients, with the significance of the drug economics.