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目的探讨汉族、维吾尔族肺结核患者血清中人肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)的含量以及民族间差异,并分析其与性别之间的关联。方法选取肺结核患者汉族132例,维吾尔族122例,用酶联免疫吸附双抗体夹心法测定患者血清中TNF-α、IL-10的含量。结果汉族和维吾尔族的肺结核患者血清中TNF-α分别为(21.72±7.18),(29.86±8.61)pg·mL~(-1);IL-10分别为(34.90±11.18),(41.65±18.11)pg·mL~(-1),差异均有统计学意义(均P<0.05)。维吾尔族肺结核患者男性与女性血清IL-10分别为(44.93±18.56),(38.95±13.13)pg·mL~(-1),差异有统计学意义(P<0.05);而TNF-α未见性别差异。汉族肺结核患者的上述因子均未见性别差异。结论新疆汉族肺结核患者血清TNF-α、IL-10含量和维吾尔族有明显差异,IL-10血清含量在维吾尔族不同性别的肺结核患者间也有差异。
Objective To investigate the levels of human tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) in Han and Uygur national tuberculosis patients as well as their inter-ethnic differences and to analyze their association with gender. Methods A total of 132 Han patients and 122 Uyghur patients with pulmonary tuberculosis were enrolled in this study. Serum levels of TNF-α and IL-10 were determined by enzyme-linked immunosorbent assay (ELISA). Results The serum levels of TNF-α in Han and Uygur nationality tuberculosis patients were (21.72 ± 7.18) and (29.86 ± 8.61) pg · mL -1, respectively. The levels of IL-10 in serum of patients with tuberculosis were (34.90 ± 11.18) and (41.65 ± 18.11) ) pg · mL ~ (-1), the difference was statistically significant (all P <0.05). The levels of IL-10 in male and female Uygur tuberculosis patients were (44.93 ± 18.56) and (38.95 ± 13.13) pg · mL -1, respectively, with statistical significance (P <0.05) Gender differences. There was no gender difference in the above factors in Han patients with pulmonary tuberculosis. Conclusion The levels of TNF-α and IL-10 in Xinjiang Han patients with tuberculosis are significantly different from those of Uygur. The serum levels of IL-10 in tuberculosis patients of different genders in Xinjiang Uygur are also different.