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为寻找新的杀虫先导化合物,采用活性亚结构拼接法,将新烟碱类和缩氨脲类杀虫剂的活性结构单元组建到同一分子中,设计合成了25个N’-硝基缩氨基胍类目标化合物,其中22个为新化合物,其结构经核磁共振氢谱和元素分析确证。初步杀虫活性测定结果表明,在500μg/mL剂量下,所有目标化合物对烟粉虱Bemisia tabaci(Gennadius)均具有一定的杀虫活性,其中化合物3e和3i的致死率达80%以上,但对粘虫Mythimna separata(Walker)则基本无活性。
In order to search for new insecticidal lead compounds, the active structural units of neonicotinoids and semicarbazones were assembled into the same molecule by the active substructural splicing method, and 25 N’-nitro-condensed Aminoguanidine target compounds, of which 22 new compounds, the structure confirmed by 1H nuclear magnetic resonance and elemental analysis. The preliminary insecticidal activity assay showed that all the target compounds had certain insecticidal activities against Bemisia tabaci (Gennadius) at the dosage of 500μg / mL, of which the lethal rates of the compounds 3e and 3i were more than 80% Mythimna separata (Walker) is essentially inactive.