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目的 研究抗人膀胱癌佐剂疫苗对人体的主动免疫治疗作用 ,为扩大临床应用提供理论依据。方法 用抗人膀胱癌抗独特型抗体主动免疫治疗膀胱癌病人 ,同时用生理盐水注射作为对照组 ,检测血清中人抗鼠抗体的产生情况 ,并检测治疗前后各项体液免疫指标及 NK细胞活性变化。结果 与对照组相比 ,治疗组病人的免疫指标上升。结论 抗人膀胱癌佐剂疫苗有增强免疫力的作用 ,有望成为膀胱癌治疗的一种新的有效手段。
Objective To study the effect of anti-human bladder cancer adjuvant vaccine on human immunization and to provide a theoretical basis for expanding clinical application. Methods The active anti-human bladder cancer anti-idiotypic antibody was used to treat bladder cancer patients. At the same time, saline was used as the control group to detect the production of human anti-mouse antibody in serum and the humoral immune indexes and NK cell activity before and after treatment Variety. Results Compared with the control group, the immune index of patients in the treatment group increased. Conclusion The anti-human bladder cancer adjuvant vaccine has the effect of enhancing immunity and is expected to become a new effective treatment for bladder cancer.