胰腺癌(PC)恶性程度高,预后极差.化疗和靶向治疗是晚期PC综合治疗的重要组成部分.近年来,晚期PC的药物研究十分活跃,笔者就新型细胞毒和靶向药物治疗进展作一综述.“,”Pancreatic cancer (PC) is one of the deadliest solid malignancies.Although surgery remains the only curative treatment,more than 80％ of patients suffer relapse after resection.More and more data evidence that PC is a systemic disease suggests systemic therapy plays crucial roles in the multidisciplinary treatment.Thus,new treatments are urgently needed for PC patients.Recently,a growing number of novel and promising drugs are being evaluated in preclinical and clinical settings.Herein,we reviewed the progress in the new cytotoxic and targeted therapy for metastatic PC.