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从梭果黄芪甲醇提取物种分离鉴定了14个化合物,经波谱数据分别鉴定为羽扇烯酮(1)、β-D-Glucopyranoside-3,4-dihydro-3-(2-hydroxy-3,4-dimethoxyphenyl)-2H-1-benzopyran-7-yl(2)、甘草素(3)、(3R)-8,2’-dihydroxy-7,4’-dimethoxyisoflavane(4)、异甘草素(5)、蔗糖(6)、7α-羟基谷甾醇(7)、3β-羟基-5α,8α-过氧化麦角甾-6,22-二烯(8)、三亚油酸甘油酯(9)、正三十三烷(10)、正十八烷(11)、二十八醇(12)、正二十七烷(13)、β-谷甾醇(14)。其中化合物1-13为首次从该植物中分离得到。活性研究结果显示,化合物2对胃癌细胞MGC-803,肝癌细胞HepG2,人卵巢癌细胞SKOV3有一定抑制作用。
Fourteen compounds were isolated and identified from the Astragalus membranaceus methanol extract from Sorbus aucuparia, identified by spectral data as lupine (1), β-D-Glucopyranoside-3,4-dihydro-3- dimethoxyphenyl) -2H-1-benzopyran-7-yl (2), liquiritigenin (3), (3R) -8,2’-dihydroxyisoflavane (4) Sucrose (6), 7α-hydroxysterol (7), 3β-hydroxy-5α, 8α-ergosta-6,22-diene oxide (8), glyceryl linoleate (9) (10), n-octadecane (11), octacosanol (12), n-heptacosane (13) and β-sitosterol (14). Among them, compound 1-13 was isolated from this plant for the first time. The results of activity study showed that compound 2 could inhibit gastric cancer cell line MGC-803, hepatoma cell line HepG2 and human ovarian cancer cell line SKOV3.