目的研究穆库尔没药Commiphora mukul树脂的化学成分。方法采用硅胶和Sephadex LH-20凝胶柱色谱法进行分离纯化,运用波谱学方法鉴定化合物的结构。结果从穆库尔没药树脂醋酸乙酯提取物中分离获得2个吉玛烷型倍半萜化合物,分别鉴定为1α,8α,12α-三羟基-2β-甲氧基-8,12-环氧吉玛烷-7(11),9-二烯-6-酮(1)和1α,8β,12α-三羟基-2β-甲氧基-8,12-环氧吉玛烷-7(11),9-二烯-6-酮(2)。结论 2个吉玛烷型倍半萜化合物1和2为未见文献报道的新化合物,分别命名为穆库尔素A(1)和穆库尔素B(2)。 Objective To study the chemical composition of Commiphora mukul resin, a myrrh medicine in Muqur. Methods The compounds were separated and purified by silica gel and Sephadex LH-20 gel column chromatography. The structures of the compounds were identified by spectroscopy. Results Two germane-type sesquiterpenoids were isolated from the muckle myrrh resin ethyl acetate extract and identified as 1α, 8α, 12α-trihydroxy-2β-methoxy-8,12-ring (1) and 1α, 8β, 12α-trihydroxy-2β-methoxy-8,12-epoxypropimane-7 (11) ), 9-dien-6-one (2). Conclusions Two germane sesquiterpene compounds 1 and 2 are new compounds which have not been reported in the literature and named as mukurin A (1) and mukurin B (2).