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苯是一种应用广泛的化工原料和环境污染物,人体长期低剂量接触后能诱导血液毒性和骨髓毒性。据报道,接苯人群中再障和急性髓性白血病的发病率增高;动物模型中诱发多种类型肿瘤。人们普遍认为苯对敏感动物的毒性来源于其代谢产物,在体内苯主要由CYP2E1(细胞色素P4502E1亚型
Benzene is a widely used chemical raw materials and environmental pollutants, the human body can induce hematotoxicity and myelotoxicity after long-term low-dose exposure. It has been reported that the incidence of aplastic anemia and acute myelogenous leukemia in the benzene-exposed population is increased; various types of tumors are induced in animal models. It is generally believed that the toxicity of benzene to sensitive animals comes from its metabolites, benzene in the body mainly by the CYP2E1 (cytochrome P450E1 subtype