论文部分内容阅读
为探讨端粒酶活性异常在胃癌发生及发展中的作用,采用TRAP银染法对胃粘膜端粒酶活性进行检测:结果端粒酶阳性率胃癌组织为100％(8/8),胃癌前状态组织为400％(4/10),浅表性胃炎为阴性(0/9)。胃癌组织阳性率最高(与其他组织比较,均P<0.05),而胃癌前状态与浅表性胃炎无显著性差异(P>0.05)。提示端粒酶激活参与胃癌的形成和发展,检测端粒酶活性可能有助于胃癌的早期诊断。
In order to investigate the role of abnormal telomerase activity in the development and progression of gastric cancer, the telomerase activity of gastric mucosa was measured by TRAP silver staining method. Results The positive rate of telomerase was 100% (8/8) in gastric cancer. The status organization was 400% (4/10) and superficial gastritis was negative (0/9). The positive rate of gastric cancer was highest (P<0.05 compared with other tissues), while there was no significant difference between pre-gastric conditions and superficial gastritis (P>0.05). It is suggested that telomerase activation is involved in the formation and development of gastric cancer. Detection of telomerase activity may contribute to the early diagnosis of gastric cancer.