论文部分内容阅读
该文探讨胃癌及癌前期病变中端粒酶活性及其临床意义。对96例胃癌患者及良性胃病在胃镜下嵌取病变部位胃黏膜5块,3块送活检,另2块则用端粒酶重复扩增法(TRAP)行端粒酶活性检测。结果表明胃癌的端粒酶阳性率为92.5%(37/40),癌前期病变的阳性率为14.2%(8/56),癌前病变中端粒酶活性随着胃黏膜发展而升高。认为端粒酶活性检测不仅可作为胃癌的特异性较强的肿瘤标记物,还可作为胃黏膜癌变的早期预测指标。
This article discusses the telomerase activity in gastric cancer and precancerous lesions and its clinical significance. In 96 gastric cancer patients and benign gastric diseases, 5 gastric lesions and 3 biopsies were taken from the lesion under endoscopy. The other two specimens were tested for telomerase activity by telomerase repeat amplification (TRAP). The results showed that the positive rate of telomerase in gastric cancer was 92.5% (37/40), the positive rate of precancerous lesions was 14.2% (8/56). The telomerase activity in precancerous lesions increased with the development of gastric mucosa. It is considered that the detection of telomerase activity not only can be used as a specific tumor marker of gastric cancer, but also as an early predictor of gastric cancer.