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目的:观察补肾疏肝方配合维生素B6治疗肾虚肝郁型高泌乳素血症的临床功效,并探讨其作用机理。方法:将60例患者随机分为两组,观察组(补肾疏肝方及维生素B6)和对照组(溴隐亭),每组各30例。观察临床综合疗效、治疗前后中医证候改善情况、血中催乳素(PRL)和相关激素水平、不良反应,并进行疗效比较。结果:观察组临床综合疗效总有效率96.55%,并显著降低PRL,对相关激素有良性调节作用,与对照组相比无统计学意义(P>0.05),但在改善中医症状及不良反应方面优于对照组(P<0.05)。结论:补肾疏肝方配合维生素B6是治疗高泌乳素血症安全而有效的方剂。
Objective: To observe the clinical efficacy of Bushen Shugan Recipe combined with vitamin B6 in the treatment of kidney deficiency and liver depression type hyperprolactinemia, and to explore the mechanism of action. Methods: Sixty patients were randomly divided into two groups: observation group (Bushen Shugan Fang and Vitamin B6) and control group (bromocriptine), 30 cases in each group. To observe the clinical efficacy, improvement of TCM syndrome before and after treatment, blood prolactin (PRL) and related hormone levels, adverse reactions, and the efficacy comparison. Results: The total effective rate of clinical observation in the observation group was 96.55%, and the PRL was significantly decreased. The benign regulation of the relevant hormones was not significant (P> 0.05). However, in improving TCM symptoms and adverse reactions Better than the control group (P <0.05). Conclusion: Bushen Shugan recipe with vitamin B6 is a safe and effective prescription for the treatment of hyperprolactinemia.