外科手术切除致灶的大力开展,为难治性癫的神经病理学研究提供了充足的病例资源。近年来,国际上关于皮质发育畸形和海马硬化的分类均有了新的研究成果和共识,同时结合分子生物学和分子遗传学的探索为我们认识癫相关病变的疾病谱系和发病机制提供了新的依据。未来几年,关于致灶的分子病理学及其致性的研究将成为热点。 Surgical resection induced focal vigorously carried out for the treatment of refractory epilepsy neuropathology provides ample case resources. In recent years, the international classification of cortical malformations and hippocampus have new research findings and consensus, combined with molecular biology and molecular genetics to explore for our understanding of epilepsy-related diseases and pedigree disease pathogenesis provides New basis. In the next few years, the research on molecular pathology and its induction of focalization will become a hot spot.