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目的探讨阿托伐他汀治疗脑血栓形成对延缓动脉粥样硬化、降低血脂的作用。方法从2011年9月至2013年9月收治的脑血栓形成患者中随机选择89例进行研究,随机分为观察组(n=45)和对照组(n=44),分别给予常规治疗和常规治疗联合阿托伐他汀治疗。比较两组血脂水平及颈动脉不良反应情况。结果治疗前两组患者的血脂水平差异均无统计学意义(P均>0.05)。治疗后两组患者的血脂水平均较治疗前降低,差异均有统计学意义(P<0.05或P<0.01)。与对照组比较,治疗后观察组血脂水平变化更明显(P均<0.05)。治疗前两组患者的颈动脉斑块面积(Smax)和颈动脉内中膜厚度(IMT)差异均无统计学意义(P均>0.05)。治疗后两组患者的IMT和Smax均较治疗前减少,差异均有统计学意义(P均<0.05)。与对照组比较,治疗后观察组IMT和Smax变化更明显,差异均有统计学意义(P均<0.05)。治疗过程中两组均无明显不良反应。结论阿托伐他汀治疗脑血栓形成可以起到良好的调脂效果,有效延缓颈动脉粥样硬化,并缩小斑块面积。
Objective To investigate the effect of atorvastatin on delayed cerebral atherosclerosis and lipid lowering in patients with cerebral thrombosis. Methods A total of 89 patients randomly selected from September 2011 to September 2013 in our department of cerebral thrombosis were randomly divided into observation group (n = 45) and control group (n = 44), and were given routine treatment and routine Treatment with atorvastatin. Blood lipid levels and carotid artery adverse reactions were compared between the two groups. Results There was no significant difference in blood lipid levels between the two groups before treatment (all P> 0.05). After treatment, the blood lipid levels of the two groups were lower than those before treatment, with statistical significance (P <0.05 or P <0.01). Compared with the control group, the changes of the blood lipid level in the observation group after treatment were more obvious (all P <0.05). There were no significant differences in carotid plaque area (IMT) and carotid IMT between the two groups before treatment (all P> 0.05). After treatment, the IMT and Smax in both groups decreased compared with before treatment, the differences were statistically significant (all P <0.05). Compared with the control group, the changes of IMT and Smax in the observation group after treatment were more obvious, the differences were statistically significant (all P <0.05). There was no significant adverse reaction in both groups during the course of treatment. Conclusion Atorvastatin treatment of cerebral thrombosis can play a good lipid-lowering effect, effectively delayed carotid atherosclerosis, and reduce plaque area.