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以二茂铁为起始原料,合成了乙酰基二茂铁,再与醛反应,合成1-二茂铁基-3-(R1苯基)-2-丙烯酮,然后再与水合肼反应合成吡唑啉,最后通过与酰氯反应生成11个N-酰基-3-二茂铁基-5-芳基吡唑啉化合物。通过1HNMR、FTIR及ESI-HRMS进行了目标化合物结构的表征;将合成的吡唑啉化合物分别对4种植物真菌病(小麦赤霉病、马铃薯干腐病、烟草赤星病、西瓜枯萎病)进行了初步的抗植物真菌活性实验,测试结果显示,部分化合物具有良好的抗植物真菌活性。
Using ferrocene as the starting material, acetyl ferrocene was synthesized and then reacted with aldehyde to synthesize 1-ferrocenyl-3- (R1phenyl) -2-propenone and then reacted with hydrazine hydrate to synthesize Pyrazoline and finally 11 N-acyl-3-ferrocenyl-5-arylpyrazoline compounds by reaction with acid chloride. The structures of the target compounds were characterized by1H NMR, FTIR and ESI-HRMS. Four fungal diseases (Fusarium head, potato dry rot, Tobacco brown spot disease, watermelon wilt) A preliminary anti-plant fungal activity test, the test results show that some compounds have good anti-plant fungal activity.