论文部分内容阅读
前列腺素与妇产科有关的有PGE_2、PGF_(2α)以及PGF_(2α)的类似物15-甲基PGF_(2α)。其主要用途: 一、足月妊娠引产:正常妊娠子宫,因为PG与孕酮之间保持一定的平衡,经常保持静止状态。如降低孕酮作用或提高PG作用,即能引起子宫收缩并导致流产或分娩。Karim(1968),Embrey(1969)等人报道用前列腺素诱发人的子宫收缩接近生理状态,对胎儿影响较小。PGE_2、PGF_(2α)及其同类物对各期妊娠子宫,均有收缩作用,尤以妊娠晚期子宫最为敏感。用其引产,主要是增加外源性前列腺素,从而干扰与孕酮的平衡状态而发生宫缩。宫缩时胎盘血流量相对减少,胎儿——胎盘功能暂时受损,于是使孕酮、雌激素分泌量减少,进而增加子宫对PG的敏感性。待宫缩逐渐增强,终于达到引产和分娩的目的。
Prostaglandins related to obstetrics and gynecology PGE_2, PGF_ (2α) and PGF_ (2α) analog 15-methyl PGF_ (2α). Its main purposes: First, full-term pregnancy induced abortion: normal pregnancy uterus, because PG and progesterone maintain a certain balance, often remain at rest. Such as reducing the role of progesterone or increase the role of PG, which can cause uterine contractions and lead to miscarriage or childbirth. Karim (1968), Embrey (1969) and others reported that prostaglandins induced contraction of human uterus close to the physiological state, the impact on the fetus smaller. PGE_2, PGF_ (2α) and its congeners on the pregnancy uterus, have contraction, especially in the third trimester of pregnancy is most sensitive. With its induction of labor, mainly to increase exogenous prostaglandin, thereby interfering with the balance of progesterone and the occurrence of contractions. Contractions placental blood flow is relatively reduced, fetal-placental function temporarily impaired, so that progesterone, estrogen secretion decreased, thereby increasing the uterine sensitivity to PG. To be gradually enhanced contractions, and finally to the induction of labor and childbirth purpose.