论文部分内容阅读
在褪黑激素的结构修饰中引入Ｌ－氨基酸形成Ｎ－（Ｎ－乙酰基－Ｌ－氨基酰基）－５－甲氧基色胺。这些化合物分别用小鼠甩尾法和人皮肤黑色素瘤细胞评价了镇痛活性和抗肿瘤活性。结果显示部分化合物的活性优于褪黑激素。
In the structural modification of melatonin, an L-amino acid was introduced to form N-(N-acetyl-L-aminoacyl)-5-methoxytryptamine. These compounds were evaluated for analgesic activity and antitumor activity using mouse tail flicking method and human skin melanoma cells, respectively. The results showed that some of the compounds had better activity than melatonin.