目的了解北京市房山区健康人群麻疹抗体水平,为采取有效的麻疹预防措施和控制策略提供科学依据。方法用容量比例概率抽样法(probability proportion to size,pps)在房山区随机选取10个村居委会,在当地连续居住6个月以上的10个年龄组人群作为研究对象,共260人。采用调查问卷收集研究对象人口学特征、含麻疹成分疫苗免疫史、麻疹患病史。采集静脉血5ml,用ELASA方法检测麻疹Ig G抗体水平。结果调查对象抗体阳性率为86.54%,标化阳性率为89.73%,抗体水平中位数为1 135.22 IU/L。不同年龄组人群中,麻疹抗体阳性率和抗体水平差异均具有统计学意义(χ2=34.77,P<0.01;H=30.61,P<0.01)。<1岁组麻疹抗体阳性率最低,为60.87%;15~19岁组抗体阳性率最高,为100.00%。1~4岁组儿童麻疹抗体水平最高,为2 743.98 IU/L;20~24岁组人群麻疹抗体水平最低,为579.37IU/L。平原、丘陵和山地三类地区人群麻疹抗体阳性率和抗体水平差异有统计学意义(χ2=11.09,P<0.01;H=8.92,P=0.01);未接种过麻疹疫苗的人群抗体阳性率和抗体水平明显低于有接种史和接种史不详的人群,差异有统计学意义(χ2=35.45,P<0.01;H=12.15,P=0.02)。结论北京市房山区常住人口中,5~19岁人群麻疹抗体水平较高,可有效阻断病毒传播,发生大范围麻疹暴发和流行的风险较小,<8月龄婴儿和20~29岁人群麻疹抗体水平有待进一步提高。 Objective To understand the level of measles antibody in healthy population in Fangshan District, Beijing, and to provide a scientific basis for effective measles prevention and control strategies. Methods The probability proportion to size (PPS) method was used to randomly select 10 village committees in Fangshan District and 260 people in 10 age groups who lived continuously for more than 6 months in Fangshan District. A questionnaire was used to collect the demographic characteristics of the study subjects, including vaccine immunization history of measles components and history of measles. Venous blood was collected 5ml, ELASA method for measles Ig G antibody levels. Results The positive rate of antibody was 86.54%, the positive rate was 89.73%, and the median antibody level was 1 135.22 IU / L. The positive rate of measles antibody and the antibody level in different age groups were statistically significant (χ2 = 34.77, P <0.01; H = 30.61, P <0.01). The measles antibody positive rate was the lowest in <1 year old group, 60.87%; the highest positive rate was 100.00% in 15 ~ 19 year old group. The measles antibody level of children aged 1 to 4 years old was the highest, which was 2 743.98 IU / L, and the lowest level of measles antibody was 579.37 IU / L among 20-24 years old group. The positive rate of antibody against measles and the level of antibody among the three groups were statistically significant (χ2 = 11.09, P <0.01; H = 8.92, P = 0.01); the positive rates of antibody in the population without measles vaccine were The antibody level was significantly lower than those with history of vaccination and history of vaccination. The difference was statistically significant (χ2 = 35.45, P <0.01; H = 12.15, P = 0.02). Conclusions Among the resident population in Fangshan district of Beijing, measles antibody level is higher among 5 ~ 19 year-olds, which can effectively block the spread of the virus, and the risk of large-scale outbreak and epidemic of measles is small. <8 months old infants and 20 ~ 29 years old population Measles antibody levels need to be further improved.