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１８０例经胃镜检查确诊为溃疡病合并幽门螺杆菌（Ｈｐ）感染患者，随机平均分为三组，Ａ组单用洛赛克，球部溃疡用６周，胃部溃疡用４周；Ｂ组用瑞贝克、甲硝唑各二周，丽珠得乐胶囊球部溃疡用６周，胃溃疡用４周；Ｃ组，洛赛克剂量、疗程同Ａ组，瑞贝克、甲硝唑、丽珠得乐剂量同Ｂ组，仅疗程为二周。疗程结束后一个月复查胃镜，显示Ｃ组Ｈｐ根除率为８５％，说明含质子泵抑制剂的四联疗法对Ｈｐ根除有很好疗效。
One hundred and eighty patients with H.pylori infection diagnosed by gastroscopy were randomly divided into three groups: group A was given Losec alone, ball ulcer was used for 6 weeks and gastric ulcer was used for 4 weeks; group B With Ribeike, metronidazole every two weeks, Livzon Dele ball capsule ulcer for 6 weeks, gastric ulcer with 4 weeks; C group, Losec dose, treatment with the A group, Rebekac, metronidazole, Beadley dose with the B group, only two weeks course of treatment. A month after the end of the course of gastroscopy review, showed that C group Hp eradication rate was 85%, indicating that the quadruple therapy with proton pump inhibitor Hp eradication has a good effect.