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为评估颈动脉体球细胞块移植治疗帕金森病 (PD)的疗效。采用立体定位注射 6 -羟多巴胺 (6 - OHDA)制备偏侧 PD大鼠模型 ,右侧纹状体内分别移植入自、异体颈动脉体和胚鼠中脑组织块 ,移植后 2、 4、 8和 12周记录阿朴吗啡诱发大鼠的旋转行为 ,测定移植区谷氨酸 (Glu)、甘氨酸 (Gly)、天门冬氨酸 (Asp)、γ-氨基丁酸 (GABA)和多巴胺 (DA)的含量改变。结果发现 :与对照组比较 ,PD大鼠阿朴吗啡诱发的旋转行为明显改善达 12周之久 ,DA水平升高显著 (P<0 .0 1)且以自体颈动脉体移植组最佳 ;自体颈动脉体移植组纹状体内 Glu和 GABA含量显著降低 (P<0 .0 1)。结果表明 :脑内移植颈动脉体球细胞块可明显改善 PD大鼠药物诱发的旋转行为 ,提高纹状体内 DA含量并降低Glu和 GABA含量 ,是一种有效治疗 PD的方法
To evaluate the efficacy of carotid body mass transfer in the treatment of Parkinson’s disease (PD). The hemiparkinsonian model rats were prepared by stereotactic injection of 6 - hydroxydopamine (6 - OHDA). The right striatum was transplanted into the autologous and allogeneic carotid body and the embryonic rat brain tissue respectively. After transplantation, 2,4, 8 And 12 weeks of apomorphine-induced rotation in rats. The levels of Glu, Gly, Asp, GABA and dopamine in the transplantation area were measured. The content of the change. The results showed that compared with the control group, the apomorphine-induced rotational behavior of PD rats significantly improved for 12 weeks, DA increased significantly (P <0.01) and autologous carotid body graft group best; autologous neck The levels of Glu and GABA in striatum of arterial grafts were significantly decreased (P <0.01). The results showed that the intracerebral transplantation of carotid body balloon block can significantly improve the drug-induced rotational behavior of PD rats, increase the content of DA in the striatum and reduce the content of Glu and GABA, which is an effective method for the treatment of PD