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目的探讨无创呼吸机辅助新活素联合小剂量呋塞米治疗急性心肌梗死合并心力衰竭对患者血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及胱抑素C(Cys-C)水平的影响。方法将228例急性心肌梗死合并心力衰竭患者随机分为观察组和对照组各114例。对照组给予新活素联合小剂量呋塞米治疗,观察组给予无创呼吸机辅助新活素联合小剂量呋塞米治疗。2组患者分别于治疗前后检测血清IL-6、TNF-α及Cys-C水平。结果治疗前2组血清IL-6、TNF-α及Cys-C水平差异无统计学意义(P>0.05)。治疗后2组血清IL-6、TNF-α及Cys-C水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05),结论无创呼吸机辅助新活素联合小剂量呋塞米治疗急性心肌梗死合并心力衰竭较新活素联合小剂量呋塞米治疗能更有效的降低患者血清IL-6、TNF-α及Cys-C水平。
Objective To investigate the effects of noninvasive ventilator-assisted neoactivity combined with low-dose furosemide in the treatment of patients with acute myocardial infarction complicated with heart failure on serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and cystatin C (Cys-C) levels. Methods A total of 228 patients with acute myocardial infarction complicated with heart failure were randomly divided into observation group and control group with 114 cases each. The control group was treated with new combination of active ingredient and low dose of furosemide. The observation group was given noninvasive ventilator-assisted neomycin combined with low-dose furosemide. The levels of serum IL-6, TNF-α and Cys-C in the two groups were measured before and after treatment. Results There was no significant difference in serum IL-6, TNF-α and Cys-C levels between the two groups before treatment (P> 0.05). The serum levels of IL-6, TNF-α and Cys-C in the two groups after treatment were lower than those before treatment, and the difference between the two groups was statistically significant (P <0.05). Conclusion Non-invasive ventilator- Combination of low-dose furosemide treatment of acute myocardial infarction with heart failure compared with new combined with small doses of furosemide treatment can be more effective in reducing serum IL-6, TNF-α and Cys-C levels.