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目的研究慢阻肺无创通气治疗患者下呼吸道真菌感染的高危因素、临床特点和预防策略。方法回顾性分析2003年3月~2006年2月本院呼吸科38例慢阻肺无创通气治疗患者下呼吸道真菌感染的临床资料。结果38例慢阻肺下呼吸道真菌感染患者共检出真菌73株,其中白色念珠菌最多见,占67.1%,合并细菌感染为78%,下呼吸道真菌感染前用过抗生素者占92%,主要是第三代头孢菌素和喹诺酮类,多为联合用药。结论下呼吸道真菌感染在慢阻肺无创通气治疗患者发病率较高,尤其是不合理使用强效、广谱抗生素及营养不良患者,治疗上消除诱因,尽早抗真菌及加强营养治疗,疗效好。
Objective To study the risk factors, clinical features and preventive strategies of lower respiratory tract fungal infection in patients with COPD. Methods The clinical data of 38 lower respiratory tract fungal infections in 38 patients with COPD underwent noninvasive ventilation in our department from March 2003 to February 2006 were retrospectively analyzed. Results A total of 73 fungi were detected in 38 cases of COPD patients, of which Candida albicans was the most common, accounting for 67.1%, with 78% of bacterial infections and 92% of antibiotics used before lower respiratory tract fungal infections. The main Is the third generation cephalosporins and quinolones, mostly for combination. Conclusion Lower respiratory tract fungal infection in patients with COPD non-invasive treatment of high incidence, especially irrational use of potent, broad-spectrum antibiotics and malnutrition patients, the treatment of the elimination of incentives, as soon as anti-fungal and nutritional therapy, good curative effect.