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观察128例,用苯巴妥治疗有效者106例,其中成人组58例,有效率95.92％,有效剂量为90～180mg/d,血中苯巴比妥浓度为19.90±7.77ug/ml;儿童70例,有效率89.47％,有效剂量为2～4mg/kg·d,血中苯巴比妥浓度为16.96±9.6ug/ml。服药剂量均与血中浓度呈正相关。1例出现中毒症状,血中苯巴比妥浓度为55μg/ml。21例治疗无效者,其主要原因可能为药物剂量不足。癫痫大发作、局限性发作、头病性及腹痛性发作的有效剂量及有效血浓度均无显著差异。
Observe 128 cases, phenobarbital effective treatment of 106 cases, of which 58 cases of adult group, the effective rate was 95.92%, the effective dose of 90 ~ 180mg / d, blood phenobarbital concentration of 19.90 ± 7.77ug / ml; children 70 cases, the effective rate of 89.47%, the effective dose of 2 ~ 4mg / kg · d, blood phenobarbital concentration of 16.96 ± 9.6ug / ml. Medication dose and blood concentrations were positively correlated. 1 case of poisoning symptoms, phenobarbital blood concentration of 55μg / ml. 21 cases of ineffective treatment, the main reason may be insufficient drug dosage. Epileptic seizures, localized attacks, headache and abdominal pain effective dose and effective blood concentration were no significant differences.