采用分光光度测定法监测了150例癫痫患者治疗中血苯巴比妥浓度,其中84例连续服药20天以上。实验结果表明,苯巴比妥服用量与其在血中的浓度呈正相关(r儿=0.847, P<0.01;r成=0.991,P<0.01)。但因个体差异,服用同样剂量的病人,血药物浓度不尽相同,提示癫痫治疗过程中,监测血苯巴比妥浓度是必要的,对指导调整用药剂量有重要参考价值。 The concentrations of phenobarbital in 150 patients with epilepsy were monitored by spectrophotometry, of which 84 were continuously treated for more than 20 days. The experimental results show that the amount of phenobarbital with its concentration in the blood was positively correlated (r = 0.847, P <0.01; r = 0.991, P <0.01). However, due to individual differences, taking the same dose of patients, blood drug concentrations vary, suggesting that during the treatment of epilepsy, monitoring of blood concentration of phenobarbital is necessary to guide the dose adjustment has important reference value.