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目的:探讨妊娠期母体血糖水平对妊娠结局的影响。方法:选取2005年1月1日~2013年12月31日在该院定期产检并分娩的16 001例单胎妊娠孕妇作为研究对象,回顾性分析不同的口服葡萄糖耐量试验(OGTT)血糖水平对妊娠结局的影响。结果:1OGTT 0h-PG水平时大于胎龄儿(LGA)和巨大儿的发生率随血糖水平显著增加;OGTT 2h-PG水平时LGA和巨大儿的发生率分别从9.2%和2.9%逐渐增加至15.2%和4.4%,经干预后LGA和巨大儿的发生率开始下降并维持平缓。2控制混杂因素后,0 h-PG及2h-PG每增加1 mmol/L发生LGA的风险分别增加44%和9%,发生巨大儿的风险分别增加82%和13%。结论:昆明地区孕妇血糖水平的升高与不良妊娠结局相关,对其进行规范化管理虽不能完全防止某些不良结局的发生,但可将LGA和巨大儿的发生率降至该院正常孕妇水平。
Objective: To investigate the effect of gestational maternal blood glucose level on pregnancy outcome. Methods: A total of 16 001 singleton pregnant women who were regularly inspected and delivered during the period from January 1, 2005 to December 31, 2013 were enrolled in this study. The blood glucose levels of different Oral Glucose Tolerance Tests (OGTT) were retrospectively analyzed Effect of pregnancy outcome. Results: The prevalence of LGA and macrosomia in 1OGTT 0h-PG increased significantly with the blood glucose level. The incidence of LGA and macrosomia gradually increased from 9.2% and 2.9% at OGTT 2h-PG level to 15.2% and 4.4% respectively. The incidence of LGA and macrosomia began to decline and remained gentle after intervention. 2 After the confounding factors were controlled, the risk of LGA increased by 44% and 9% for each additional 1 mmol / L of 0 h-PG and 2 h-PG, and the risks of macrosomia increased by 82% and 13% respectively. Conclusion: The elevated blood glucose level of pregnant women in Kunming area is related to adverse pregnancy outcomes. Although standardized management can not completely prevent some adverse outcomes, the incidence of LGA and giant macrosomia may be reduced to the level of normal pregnant women in this hospital.