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袁某,男,58岁,退休工人,患风湿性关节炎八年余。抗风湿药物治疗未间断,曾多次注射青霉素、口服头孢族药物,未见明显不适。1995年5月25日晚8时,患者口服头孢氨苄0.5克,布洛芬0.2克,消炎痛25毫克。两分钟后,双小腿部开始瘙痒,尔后感觉上腹部不适,心慌,呼吸困难,5分钟后,四肢奇痒难忍,眼睑、口唇肿胀、眼圈发青,指甲青紫,继而有大便感,便后,视物模糊,大汗淋漓,呕吐粘沫数口,脉弱。考虑为药物过敏所致,服用强地松20毫克和抗组织胺药物及对症治疗,症状缓解。次日面部皮肤潮红,口唇、眼睑水肿,腕关节、踝关节高度水肿,四肢出现大小不
Yuan Mou, male, 58 years old, retired workers, suffering from rheumatoid arthritis more than eight years. Anti-rheumatic drug treatment is not interrupted, had multiple injections of penicillin, oral cephalosporin drugs, no obvious discomfort. On the evening of May 25, 1995, at 8 o’clock, patients took oral cefalexin 0.5g, ibuprofen 0.2g and indomethacin 25mg. After two minutes, both legs began to itch, then feel the upper abdomen discomfort, palpitation, difficulty breathing, 5 minutes later, limbs itchy unbearable, eyelids, lips swollen, eye ring blue, fingernail bruising, followed by stool, then After the blurred vision, sweating, vomiting sticky foam mouth, pulse weak. Considered to be caused by drug allergies, taking prednisone 20 mg and antihistamine drugs and symptomatic treatment, relieve symptoms. The next day, facial skin flushing, lips, eyelid edema, wrist, ankle height edema, limbs appear not the size