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目的 探讨用外源性肺表面活性物质 (PS)治疗肺透明膜病 (HMD)的方法及效果。方法 采用气管插管、从气管内滴入PS ,用药前吸净呼吸道分泌物。结果 用药后 ,HMD患儿症状、体征渐减轻直至消失 ,动脉血氧分压 (PaO2 )、经皮血氧饱和度 (TcSaO2 )升高 ,动脉血二氧化碳分压降低 ,12h后 ,PaO2 ,PaCO2 ,TcSaO2 已达正常。 2 4h后 ,胸片示肺充气好转 ,透亮度增加。结论 PS能改善HMD患儿肺顺应性及氧合功能 ,使用时应注意方法。
Objective To investigate the method and effect of exogenous pulmonary surfactant (hm) treatment of hyaline membrane disease (HMD). Methods Tracheal intubation, tracheal instillation of PS, inhaled net respiratory secretions. Results After treatment, the symptoms and signs of HMD decreased gradually until disappeared. PaO2, TcSaO2 increased and arterial partial pressure of carbon dioxide decreased. After 12h, PaO2, PaCO2, TcSaO2 has reached normal. 2 4h, chest radiograph showed improved lung, increased brightness. Conclusions PS can improve lung compliance and oxygenation in children with HMD, and should be paid attention to when used.