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我们对原发性肝癌进行了1∶2病例对照研究,结果显示:PHC病人HBV感染标志及家族肝病史的比例明显高于对照组,相对危险性(RR)分别是对照组的9.75及25.0倍;PHC病人HBsAg的几何平均滴度(1∶83)明显低于对照组(1∶251),抗-HBc的几何平均滴度(1∶489.8)则显著高于对照组(1∶138);PHC病人HBV感染标志无明显的地区性差异。有关吸烟、饮酒等因素未显示统计学意义,从而进一步验证了HBV感染与PHC发病的病因学联系。
We conducted a 1: 2 case-control study of primary hepatocellular carcinoma. The results showed that the proportion of HBV infection markers and family history of liver disease in PHC patients was significantly higher than that of the control group, and the relative risk (RR) was 9.75 and 25.0 times that of the control group . The mean geometric mean HBsAg titer (1:83) in PHC patients was significantly lower than that in control group (1:251). The geometric mean titer of anti-HBc (1:489.8) was significantly higher than that of control group (1:138). There was no obvious regional difference in HBV infection sign in PHC patients. Smoking, drinking and other factors did not show statistical significance, thus further verifying the etiology of HBV infection and PHC incidence.